Close X
Tuesday, November 12, 2024
ADVT 
Newsmakers

Indian scientist Dr. Asis Bala and his team develop new treatments for type I and autoimmune diabetes

Darpan News Desk IANS, 05 Nov, 2024 02:36 PM
  • Indian scientist Dr. Asis Bala and his team develop new treatments for type I and autoimmune diabetes

New Delhi, Nov 5 (IANS) Scientists at the Institute of Advanced Study in Science and Technology (IASST) in Guwahati, an autonomous institute under the Department of Science and Technology, have discovered a specific protein IL-35 that can aid in new treatments for type I and autoimmune diabetes mellitus.

IL-35 is a specific protein of IL-12 alpha and IL-27 beta chains which is encoded by the IL12A and EBI3 genes.

The IASST team showed that IL-35 protects the immune system by lowering particular immune cells that produce inflammatory chemicals. This can help reduce pancreatic cell infiltration -- a key contributor to type 1 diabetes and autoimmune diabetes mellitus.

“This protein presents a novel diabetes treatment option,” said the scientists, even as the global diabetes epidemic is growing.

Diabetes disproportionately affects developing country children and adolescents calls for effective treatment for the disease.

In the study, the team led by Dr. Asis Bala, Associate Professor, conducted a network pharmacological analysis of IL-35-related genes, gene-disease associations, and a comprehensive experiment review.

Using the network pharmacological analysis, they identified five disease-interacting genes associated with immune-inflammatory, autoimmune, neoplastic, and endocrine disorders.

The findings, published in the journals CYTOKINE and World Journal of Diabetes, showed that IL-35 can protect against type 1 and autoimmune diabetes.

“It regulates macrophage activation, T-cell proteins, and regulatory B cells,” the team said. They explained that IL-35 stops pancreatic beta cells from attacking immune cells.

Further, the protein also lowers particular immune cells that produce inflammatory chemicals, reducing pancreatic cell infiltration -- a key contributor in type 1 diabetes and autoimmune diabetes mellitus.

The study implies that “IL-35 protects the immune system, presenting a novel diabetes treatment option,” said the researchers, while calling for more studies to understand the mechanisms and advance IL-35-based therapeutics into clinical trials.

Photo courtesy of LinkedIn (@Dr.AsisBhala)

MORE Newsmakers ARTICLES

Essar Group appoints Manu Kapoor as Group Chief of Public Policy and Corporate Affairs

Essar Group appoints Manu Kapoor as Group Chief of Public Policy and Corporate Affairs
Essar Group on Friday announced the appointment of Manu Kapoor as its Group Chief of Public Policy and Corporate Affairs. Kapoor brings over three decades of specialised experience working with corporations, governments, public sector agencies, and industry groups.

Essar Group appoints Manu Kapoor as Group Chief of Public Policy and Corporate Affairs

Bharti Airtel names COO Shashwat Sharma as MD and CEO; Vittal moves into bigger role

Bharti Airtel names COO Shashwat Sharma as MD and CEO; Vittal moves into bigger role
On January 1, 2026, Vittal will move into the role of Executive Vice Chairman of Bharti Airtel. Shashwat Sharma, currently Chief Operation Officer (COO), will be appointed MD and CEO of Bharti Airtel on January 1, informed the company. While continuing to lead the India business, Vittal will take on broader telecom responsibilities across the group.

Bharti Airtel names COO Shashwat Sharma as MD and CEO; Vittal moves into bigger role

Indian-origin scientist discovers protein function that may treat age-related diseases

Indian-origin scientist discovers protein function that may treat age-related diseases
A team of researchers, led by an Indian-origin scientist, has discovered new function of a protein that may treat age-related illnesses. The team from McMaster University in Canada found a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier ageing.

Indian-origin scientist discovers protein function that may treat age-related diseases

Amazon appoints Samir Kumar as India operations head

Amazon appoints Samir Kumar as India operations head
E-commerce giant Amazon on Wednesday appointed Samir Kumar as the country manager for India after the abrupt exit of Manish Tiwary. Kumar, an Amazon veteran since 1999, is expected to assume operational responsibilities for India starting October 1, according to a company update today.

Amazon appoints Samir Kumar as India operations head

India poised to become global AI hub: Tech futurist Stephen Ibaraki

India poised to become global AI hub: Tech futurist Stephen Ibaraki
To become a global artificial intelligence (AI) hub, India needs to leverage its vast talent pool and establish AI-focused centres of excellence in collaboration with academic institutions and industry leaders, Stephen Ibaraki, a technology futurist and global thought leader, said on Saturday. Ibaraki said the country, with its robust digital infrastructure, needs to continue investing in AI research and development, and creating a conducive environment for startups and innovation.

India poised to become global AI hub: Tech futurist Stephen Ibaraki

Daily workout is necessary: Ankit Baiyanpuria at National Creators Award

Daily workout is necessary: Ankit Baiyanpuria at National Creators Award
The YouTuber with 3.8 million subscribers recently made headlines for his "75-day hard challenge," a rigorous regimen emphasising mental health, well-being and discipline.

Daily workout is necessary: Ankit Baiyanpuria at National Creators Award

PrevNext