RCMP in Surrey, B.C., say a teenager has died from his injuries after he was stabbed while aboard a transit bus in the city.
Police say the stabbing happened just before 9:30 Tuesday night.
Investigators say the 17-year-old victim and his attacker had some sort of altercation while on the bus, not far from the King George SkyTrain station.
Police are still seeking witnesses but say it appears the stabbing was "targeted" and an "isolated incident."
No arrests have been made, and the Integrated Homicide Investigation Team, or IHIT, has been called in to investigate.
The attack is the second serious stabbing in as many days at a Metro Vancouver transit location.
On Monday night, a victim was attacked at the Columbia SkyTrain Station in New Westminster.
The victim in the New Westminster stabbing was treated in hospital and their condition has not been released. Police are searching for three suspects, two men and a female teenager, in that incident.
The latest attack is also the second serious stabbing in two weeks aboard a transit bus in Surrey, although the first victim, whose throat was slashed on April 1, is now recovering at home.
Police say there are "no indications" that two bus attacks are "in any way connected."
Abdul Aziz Kawam, the suspect in the April 1 throat-slashing, is scheduled to reappear in court in Surrey on Thursday.
Kawam is charged with attempted murder, assault causing bodily harm, aggravated assault and assault with a weapon, all in association with the Islamic State terrorist group.