Close X
Thursday, November 28, 2024
ADVT 
Health

New treatment for gum disease in diabetics

Darpan News Desk IANS, 01 Aug, 2014 09:10 AM
    Going to the dentist may not be fun but for those with periodontal disease related to type-two diabetes, a new research may bring back their smile.
     
    Scientists have found that B cells - one of the most important blood cells involved in the human immune response - are shown to promote inflammation and bone loss in type-two diabetes-associated periodontal disease.
     
    The treatments that manipulate the responses of B cells may treat or prevent the symptoms of type-two diabetes and periodontitis or pyorrhea simultaneously.
     
    "Our study paves the way for the development of novel therapeutics which aim to simultaneously treat both type-two diabetes and its complications," said Min Zhu, a researcher from department of microbiology at Boston University's school of medicine.
     
    To make this discovery, scientists used a mouse model of periodontal disease and applied it to two groups.
     
    The first group had a genetic alteration that knocked out all B cells.
     
    The second group had normal B cell levels.
     
    When fed a low-fat diet, without development of obesity and type-two diabetes, both groups demonstrated a similar extent of oral bone loss and inflammation.
     
    However, when they were fed a high-fat diet, oral bone loss and inflammation occurred in the normal group with B cells but did not develop in the group that had a genetic alteration that knocked out all B cells.
     
    This suggests that the B cell-response might be a viable target for pharmacological intervention in both type-two diabetes and periodontal disease, as well as potentially in other type-two diabetes complications.
     
    The research was published in the Journal of Leukocyte Biology.

    MORE Health ARTICLES

    'Revolutionary' antibiotics to tackle TB

    'Revolutionary' antibiotics to tackle TB
    Why mycobacteria - a family that includes the microbe that causes tuberculosis (TB) - survive oxygen limitation has long been a mystery but not any more....

    'Revolutionary' antibiotics to tackle TB

    'Simulated' human heart created for better drug testing

    'Simulated' human heart created for better drug testing
    In pioneering research, a scientist has developed a 'simulated' human heart to test the effect of drugs on the heart without using human or animal trials....

    'Simulated' human heart created for better drug testing

    Avian influenza treatments identified

    Avian influenza treatments identified
    In a novel discovery, scientists have identified six potential therapeutics to treat the deadly H7N9 avian influenza...

    Avian influenza treatments identified

    Genes play key role in twins' language deficit

    Genes play key role in twins' language deficit
    Contrary to the popular tendency to attribute delays in early language acquisition of twins to mothers, researchers have found that genes play a significant role in...

    Genes play key role in twins' language deficit

    Scaling up HIV therapy can end this epidemic by 2030: UNAIDS

    Scaling up HIV therapy can end this epidemic by 2030: UNAIDS
    The opening session of the 20th International AIDS Conference (AIDS 2014) began here Sunday with tributes being paid to the six delegates who...

    Scaling up HIV therapy can end this epidemic by 2030: UNAIDS

    Gene behind benign breast tumours identified

    Gene behind benign breast tumours identified
    Researchers have identified a critical gene that could help clinicians distinguish fibroadenomas cases from breast cancer. Fibroadenomas is the most...

    Gene behind benign breast tumours identified