Canadian researchers have identified how vitamin K helps prevent diabetes, a finding that could lead to new therapeutic applications for a disease that affects one in 11 people worldwide and has no cure.
Several studies have previously suggested a link between a reduced intake of vitamin K and an increased risk of diabetes. However, the biological mechanisms by which vitamin K protects against diabetes remained a mystery until now.
The team from the Universite de Montreal (UdeM) found a potentially protective role of vitamin K and gamma-carboxylation in beta cells.
Vitamin K is a micronutrient known for its role in blood clotting, in particular in gamma-carboxylation -- an enzymatic reaction essential to the process.
The study, published in the journal Cell Reports, determined that the enzymes involved in gamma-carboxylation and therefore in the use of vitamin K were present in large quantities in pancreatic beta cells, the very cells that produce the precious insulin that controls blood sugar levels.
"Diabetes is known to be caused by a reduction in the number of beta cells or by their inability to produce enough insulin, hence our keen interest in this novel finding," said Mathieu Ferron, associate research professor of medicine at UdeM.
"We were able to identify a new gamma-carboxylated protein called ERGP," added Julie Lacombe, who conducted the work in Ferron's laboratory.
"Our study shows that this protein plays an important role in maintaining physiological levels of calcium in beta cells in order to prevent a disturbance of insulin secretion. Finally, we showed that vitamin K through gamma-carboxylation is essential for ERGP to perform its role."
This is the first time in 15 years that a novel vitamin K-dependent protein has been identified, opening a new field of research in this area.
With an abundance of food options available, it's important to approach meal planning with a strategy that aligns with your health goals. Whether you're looking to lose weight, manage a medical condition, or simply try out a new diet, effective meal planning is crucial. Here are three steps to help you get started.
Stress, anxiety, and hypertension are now widespread health problems that impact millions of individuals globally in today's fast-paced society. Here are 5 meditation techniques like Mindfulness Meditation, Love-Kindness Meditation, etc. to deal with these issues.
Only in this mindful state can you take charge of the inner dialogue and set clear intentions for your health. Research shows that harnessing the power of intent is very effective because intent informs your outcomes.
Incorporating healthy smoothies and juices into our diet is one effective and delicious way to achieve high energy levels and vitality. Here are some of the variety of refreshing and revitalizing smoothie and juice recipes that will boost your energy and enliven your day
So, let's explore and have a quick look at how using essential oils or soothing fragrances of an incense stick can make your yoga experience better highlighted by Amita Agrawal, Head-Perfumery Division and Director, Mysore Deep Perfumery House (Zed Black).
