The caption is directed to online "trolls" who she says write "unkind things." She writes, "This is how I look. I feel happy" before adding that she thinks she looks "strong and healthy."
Slamming body critics is nothing new for Schumer. She told Glamour magazine it was "not cool" in another Instagram post last month for mentioning her in an issue focused on plus size fashion.
She wrote that there's nothing wrong with being plus-size, but disputed having a plus-size body, suggesting that labeling her body type that way could have a negative influence on young girls.
Singer Madonna tried to defend her former husband and actor Sean Penn over "Empire" co-creator Lee Daniels' controversial comments in which he compared Penn to Terrence Howard, who admitted to hitting women.