The caption is directed to online "trolls" who she says write "unkind things." She writes, "This is how I look. I feel happy" before adding that she thinks she looks "strong and healthy."
Slamming body critics is nothing new for Schumer. She told Glamour magazine it was "not cool" in another Instagram post last month for mentioning her in an issue focused on plus size fashion.
She wrote that there's nothing wrong with being plus-size, but disputed having a plus-size body, suggesting that labeling her body type that way could have a negative influence on young girls.
Actor Charlie Sheen, who is HIV-positive, says he was so angry that he contracted the disease that he told his mother that he would "discover a cure" for it.
At 12:01 a.m. local time on Dec. 24 around the world, the Beatles' music will be available for streaming from a wide range of outlets, a representative announced Wednesday.